Research Interests
Antimicrobial Peptides:
Mechanism of AMP
Energetics of Pore Formation
Toroidal vs. Barrel Stave Model
Observation of Pores
Peptide Orientation Change
Membrane Thinning Effect
Concentration Dependence
Experimental Methods:
Oriented Circular Dichroism
In-plane Scattering
Diffraction Techniques
Lipid Dynamics by IXS
Anomalous Diffraction
Peptide-Lipid Interact:
Hydrophobic Matching
Membrane-mediated Protein Interactions
Elasticity Theory and Thermodynamics
Fusion and Lipids:
Bending & Lipid Demixing
Chain Volume Conservation
LPS and others
Gramicidin Problems:
Channel Poperties
Model Studies
Huey W. Huang - Sam and Helen Worden Chair Professor
Department of Physics & Astronomy - Rice University - phone: 713-348-4889 - fax: 713-348-4150
LPS and Other Lipids

Lipopolysaccharides (LPS)

L. Ding, L. Yang, T. M. Weiss, A. J. Waring, R. I. Lehrer, and H. W. Huang, “Interaction of antimicrobial peptides with lipopolysaccharides” Biochemistry 42: 12251-12259 (2003).

New Phases

L. Yang and H. W. Huang, “Observation of a membrane fusion intermediate structure,” Science 297: 1877-1879 (2002)

L. Yang, L. Ding and H. W. Huang, “New Phases of Phospholipids and Implications to the membrane fusion problem”, Biochemistry 42: 6631-6635(2003)

Structure of hexagonal phase

L. Ding, W. Liu, W. Wang, C. Glinka, D. L. Worcester, L. Yang, and H. W. Huang. "Diffraction techniques for non-lamellar phases of phospholipids." Langmuir 20: 9262-9269 (2004).

Structure of distorted hexagonal phase

L. Ding, T. M. Weiss, G. Fragneto, W. Liu, L. Yang, and H. W. Huang, "Distorted hexagonal phase studied by neutron diffraction: lipid components demixed in a bent monolayer." Langmuir in press.

Diphytanoyl phasphatidylcholine

W. C. Hung, F. Y. Chen and H. W. Huang, “Order-disorder transition in bilayers of diphytanoyl phosphatidylcholine,” Biochim. Biophys. Acta 1467: 198-206 (2000)

L. Yang and H. W. Huang, “Observation of a membrane fusion intermediate structure,” Science 297: 1877-1879 (2002)

Critical Swelling

F. Y. Chen, W. C. Hung, and H. W. Huang, "Critical swelling of phospholipid bilayers," Phys. Rev. Lett. 79: 4026-4029 (1997).

Headgroup size effect

W. T. Heller, K. He, S. J. Ludtke, T. A. Harroun, and H. W. Huang, "Effect of changing the size of lipid headgroup on peptide insertion into membrane," Biophys. J. 73: 239-244 (1997)