Research Interests
Antimicrobial Peptides:
Mechanism of AMP
Energetics of Pore Formation
Toroidal vs. Barrel Stave Model
Observation of Pores
Peptide Orientation Change
Membrane Thinning Effect
Concentration Dependence
Experimental Methods:
Oriented Circular Dichroism
In-plane Scattering
Diffraction Techniques
Lipid Dynamics by IXS
Anomalous Diffraction
Peptide-Lipid Interact:
Hydrophobic Matching
Membrane-mediated Protein Interactions
Elasticity Theory and Thermodynamics
Fusion and Lipids:
Bending & Lipid Demixing
Chain Volume Conservation
LPS and others
Gramicidin Problems:
Channel Poperties
Model Studies
Huey W. Huang - Sam and Helen Worden Chair Professor
Department of Physics & Astronomy - Rice University - phone: 713-348-4889 - fax: 713-348-4150

Membrane Thinning Effect

Y. Wu, K. He, S. J. Ludtke, and H. W. Huang, “X-ray Diffraction Study of Lipid Bilayer Membrane Interacting with Amphiphilic Helical Peptides: Diphytanoyl Phosphatidylcholine with Alamethicin at Low Concentrations” Biophys. J. 68, 2361-2369 (1995).

S. J. Ludtke, K. He, and H. W. Huang, "Membrane Thinning Caused by Magainin 2" Biochemistry 34: 16764-16769 (1995)

W. T. Heller, A. J. Waring, R. I. Lehrer, T. A. Harroun, T. M. Weiss, L. Yang, and H. W. Huang, “Membrane Thinning Effect by the b-sheet Antimicrobial Protegrin.” Biochemistry 39, 139-145 (2000).

F. Y. Chen, M. T. Lee and H. W. Huang, “Evidence for membrane thinning effect as the mechanism for peptide-induced pore formation,” Biophys. J. 84: 3751-3758 (2003)

M. T. Lee, F. Y. Chen and H. W. Huang, "Energetics of pore formation induced by antimicrobial peptides" Biochemistry 43: 3590-3599 (2004).

H. W. Huang, F. Y. Chen and M. T. Lee, "Molecular mechanism of peptide induced pores in membranes" Phys. Rev. Lett. 92: 198304(1-4) (2004).