Research Interests
Antimicrobial Peptides:
Mechanism of AMP
Energetics of Pore Formation
Toroidal vs. Barrel Stave Model
Observation of Pores
Peptide Orientation Change
Membrane Thinning Effect
Concentration Dependence
Experimental Methods:
Oriented Circular Dichroism
In-plane Scattering
Diffraction Techniques
Lipid Dynamics by IXS
Anomalous Diffraction
Peptide-Lipid Interact:
Hydrophobic Matching
Membrane-mediated Protein Interactions
Elasticity Theory and Thermodynamics
Fusion and Lipids:
Bending & Lipid Demixing
Chain Volume Conservation
LPS and others
Gramicidin Problems:
Channel Poperties
Model Studies
Huey W. Huang - Sam and Helen Worden Chair Professor
Department of Physics & Astronomy - Rice University - phone: 713-348-4889 - fax: 713-348-4150
Peptide Orientation Change

H. W. Huang and Y. Wu, "Lipid-Alamethicin Interactions Influence Alamethicin Orientation." Biophys. J. 60, 1079-1087 (1991).

S. J. Ludtke, K. He, Y. Wu, and H. W. Huang, “Cooperative Membrane Insertion of Magainin Correlated with Its Cytolytic Activity” Biochim. Biophys. Acta 1190, 181-184 (1994)

W. T. Heller, K. He, S. J. Ludtke, T. A. Harroun, and H. W. Huang, "Effect of changing the size of lipid headgroup on peptide insertion into membrane," Biophys. J. 73: 239-244 (1997)

W. T. Heller, A. J. Waring, R. I. Lehrer, H. W. Huang, “Multiple states of beta-sheet peptide protegrin in lipid bilayers,” Biochemistry 37: 17331-17338 (1998)

L. Yang, T. A. Harroun, T. M. Weiss, L. Ding and H. W. Huang, “Barrel-stave Model or Toroidal Model? A Case Study on Melittin Pores,” Biophys. J. 81: 1475-1485 (2001)

T. M. Weiss, L. Yang, L. Ding, A. J. Waring, R. I. Lehrer, and H. W. Huang, “Two states of cyclic antimicrobial peptide RTD-1 in lipid bilayers” Biochemistry 41: 10070-10076 (2002)

F. Y. Chen, M. T. Lee and H. W. Huang, “Sigmoidal concentration dependence of antimicrobial peptide activities: a case study on alamethicin,” Biophys. J. 82: 908-914 (2002).

F. Y. Chen, M. T. Lee and H. W. Huang, “Evidence for membrane thinning effect as the mechanism for peptide-induced pore formation,” Biophys. J. 84: 3751-3758 (2003)

M. T. Lee, F. Y. Chen and H. W. Huang, "Energetics of pore formation induced by antimicrobial peptides" Biochemistry 43: 3590-3599 (2004).