Research Interests
Publications
Topics:
Antimicrobial Peptides:
Mechanism of AMP
Energetics of Pore Formation
Toroidal vs. Barrel Stave Model
Observation of Pores
Peptide Orientation Change
Membrane Thinning Effect
Concentration Dependence
Magainin
Protegrin
theta-Defensin
Alamethicin
Melittin
Experimental Methods:
Oriented Circular Dichroism
In-plane Scattering
Diffraction Techniques
Lipid Dynamics by IXS
Anomalous Diffraction
Peptide-Lipid Interact:
Hydrophobic Matching
Membrane-mediated Protein Interactions
Elasticity Theory and Thermodynamics
Fusion and Lipids:
Stalk
Bending & Lipid Demixing
Chain Volume Conservation
LPS and others
Gramicidin Problems:
Channel Poperties
Model Studies
 
Huey W. Huang - Sam and Helen Worden Chair Professor
Department of Physics & Astronomy - Rice University
hwhuang@rice.edu - phone: 713-348-4889 - fax: 713-348-4150

Diffraction Techniques

1) Off-plane Scattering

L. Yang, T. A. Harroun, W. T. Heller, T. M. Weiss, and H. W. Huang, “Neutron off-plane scattering of aligned membranes I.Method of measurement,” Biophys. J. 75: 641-645 (1998).

L. Yang, T. M. Weiss, T. A. Harroun, W. T. Heller, and H. W. Huang, “Supramolecular Structures of Peptide Assemblies in Membranes by Neutron Off-plane Scattering: Method of Analysis” Biophys. J. 77:2648-2656. (1999)

 

2) Grazing Incident Small Angle Diffraction

L. Yang and H. W. Huang. A rhombohedral phase of lipid containing a membrane fusion intermediate structure. Biophys. J. 84, 1808-1817 (2003)

L. Ding, W. Liu, W. Wang, C. Glinka, D. L. Worcester, L. Yang, and H. W. Huang. "Diffraction techniques for non-lamellar phases of phospholipids." Langmuir 20: 9262-9269 (2004).

 

3) Phasing Methods

Liu, W., T. Y. Teng, Y. Wu, and H. W. Huang, “Phase Determination for Membrane Diffraction by Anomalous Dispersion.” Acta Cryst. A47, 553-559 (1991).

L. Ding, W. Liu, W. Wang, C. Glinka, D. L. Worcester, L. Yang, and H. W. Huang. "Diffraction techniques for non-lamellar phases of phospholipids." Langmuir 20: 9262-9269 (2004).

 

4) Crystallization Of Membrane Structures

L. Yang, T. M. Weiss, and H. W. Huang, “Crystallization of antimicrobial pores in membranes: Magainin and protegrin,” Biophys. J. 79: 2002-2009 (2000)

L. Yang and H. W. Huang, “Observation of a membrane fusion intermediate structure,” Science 297: 1877-1879 (2002)