Research Interests
Antimicrobial Peptides:
Mechanism of AMP
Energetics of Pore Formation
Toroidal vs. Barrel Stave Model
Observation of Pores
Peptide Orientation Change
Membrane Thinning Effect
Concentration Dependence
Experimental Methods:
Oriented Circular Dichroism
In-plane Scattering
Diffraction Techniques
Lipid Dynamics by IXS
Anomalous Diffraction
Peptide-Lipid Interact:
Hydrophobic Matching
Membrane-mediated Protein Interactions
Elasticity Theory and Thermodynamics
Fusion and Lipids:
Bending & Lipid Demixing
Chain Volume Conservation
LPS and others
Gramicidin Problems:
Channel Poperties
Model Studies
Huey W. Huang - Sam and Helen Worden Chair Professor
Department of Physics & Astronomy - Rice University - phone: 713-348-4889 - fax: 713-348-4150
Elasticity Theory and Thermodynamics


H. W. Huang, "Deformation Free Energy of Bilayer Membrane and Its Effect on Gramicidin Channel Lifetime," Biophys. J. 50,1061-1071 (1986).

H. W. Huang, "Elasticity of Lipid Bilayer Interaction with Amphiphilic Helical Peptides" J. Phys. II France 5: 1427-1431 (1995).

T. A. Harroun, W. T. Heller, T. M. Weiss, L. Yang, and H. W. Huang, “Theoretical analysis of hydrophobic matching and membrane-mediated interactions in lipid bilayers containing gramicidin,” Biophys. J. 76: 3176-3185 (1999)

H. W. Huang, F. Y. Chen and M. T. Lee, "Molecular mechanism of peptide induced pores in membranes" Phys. Rev. Lett. 92: 198304(1-4) (2004).

M. T. Lee, F. Y. Chen and H. W. Huang, "Energetics of pore formation induced by antimicrobial peptides" Biochemistry 43: 3590-3599 (2004).