Research Interests
Publications
Topics:
Antimicrobial Peptides:
Mechanism of AMP
Energetics of Pore Formation
Toroidal vs. Barrel Stave Model
Observation of Pores
Peptide Orientation Change
Membrane Thinning Effect
Concentration Dependence
Magainin
Protegrin
theta-Defensin
Alamethicin
Melittin
Experimental Methods:
Oriented Circular Dichroism
In-plane Scattering
Diffraction Techniques
Lipid Dynamics by IXS
Anomalous Diffraction
Peptide-Lipid Interact:
Hydrophobic Matching
Membrane-mediated Protein Interactions
Elasticity Theory and Thermodynamics
Fusion and Lipids:
Stalk
Bending & Lipid Demixing
Chain Volume Conservation
LPS and others
Gramicidin Problems:
Channel Poperties
Model Studies
 
Huey W. Huang - Sam and Helen Worden Chair Professor
Department of Physics & Astronomy - Rice University
hwhuang@rice.edu - phone: 713-348-4889 - fax: 713-348-4150
Using Gramicidin for Model Studies

Hydrophobic matching

H. W. Huang, "Deformation Free Energy of Bilayer Membrane and Its Effect on Gramicidin Channel Lifetime," Biophys. J. 50,1061-1071 (1986).

T. A. Harroun, W. T. Heller, T. M. Weiss, L. Yang, and H. W. Huang, “Experimental evidence of hydrophobic matching and membrane-mediated interactions in lipid bilayers containing gramicidin,” Biophys. J. 76: 937-945 (1999)

In-plane distribution and membrane-mediated protein interactions

K. He, S. J. Ludtke, Y. Wu, and H. W. Huang, “X-ray Scattering with Momentum Transfer in the Plane of Membrane: Application to Gramicidin Organization.” Biophys. J. 64, 157-162 (1993)

K. He, S. J. Ludtke, Y. Wu, and H. W. Huang, “X-ray Scattering in the Plane of Membrane” J. Phys. IV (France) 3, 265-270 (1993).

K. He, S. J. Ludtke, Y. Wu, H. W. Huang, O.S. Andersen, D. Greathouse and R. E. Koeppe, “Closed State of Gramicidin Channel Detected by X-ray In-Plane Scattering” Biophys. Chem. 49, 83-89 (1994).

T. A. Harroun, W. T. Heller, T. M. Weiss, L. Yang, and H. W. Huang, “Experimental evidence of hydrophobic matching and membrane-mediated interactions in lipid bilayers containing gramicidin,” Biophys. J. 76: 937-945 (1999)

L. Yang, T. M. Weiss, T. A. Harroun, W. T. Heller, and H. W. Huang, “Supramolecular Structures of Peptide Assemblies in Membranes by Neutron Off-plane Scattering: Method of Analysis” Biophys. J. 77:2648-2656. (1999)

Size of channels

L. Yang, T. M. Weiss, T. A. Harroun, W. T. Heller, and H. W. Huang, “Supramolecular Structures of Peptide Assemblies in Membranes by Neutron Off-plane Scattering: Method of Analysis” Biophys. J. 77:2648-2656. (1999)