Research Interests
Antimicrobial Peptides:
Mechanism of AMP
Energetics of Pore Formation
Toroidal vs. Barrel Stave Model
Observation of Pores
Peptide Orientation Change
Membrane Thinning Effect
Concentration Dependence
Experimental Methods:
Oriented Circular Dichroism
In-plane Scattering
Diffraction Techniques
Lipid Dynamics by IXS
Anomalous Diffraction
Peptide-Lipid Interact:
Hydrophobic Matching
Membrane-mediated Protein Interactions
Elasticity Theory and Thermodynamics
Fusion and Lipids:
Bending & Lipid Demixing
Chain Volume Conservation
LPS and others
Gramicidin Problems:
Channel Poperties
Model Studies
Huey W. Huang - Sam and Helen Worden Chair Professor
Department of Physics & Astronomy - Rice University - phone: 713-348-4889 - fax: 713-348-4150

Gramicidin Channel Properties

Ion bind sites


G. A. Olah, H. W. Huang, W. Liu and Y. Wu, "Location of Ion Binding Sites in the Gramicidin Channel by X-ray Diffraction." J. Mol. Biol. 218, 847-858 (1991).

Liu, W., T. Y. Teng, Y. Wu, and H. W. Huang, “Phase Determination for Membrane Diffraction by Anomalous Dispersion.” Acta Cryst. A47, 553-559 (1991).

Chanel lifetime and membrane thickness

H. W. Huang, "Deformation Free Energy of Bilayer Membrane and Its Effect on Gramicidin Channel Lifetime," Biophys. J. 50,1061-1071 (1986).

T. A. Harroun, W. T. Heller, T. M. Weiss, L. Yang, and H. W. Huang, “Theoretical analysis of hydrophobic matching and membrane-mediated interactions in lipid bilayers containing gramicidin,” Biophys. J. 76: 3176-3185 (1999)

Monomeric state

K. He, S. J. Ludtke, Y. Wu, H. W. Huang, O.S. Andersen, D. Greathouse and R. E. Koeppe, “Closed State of Gramicidin Channel Detected by X-ray In-Plane Scattering” Biophys. Chem. 49, 83-89 (1994).